Asian Journal of Research in Nephrology https://journalajrn.com/index.php/AJRN <p style="text-align: justify;"><strong>Asian Journal of Research in Nephrology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRN/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Nephrology research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> Asian Journal of Research in Nephrology en-US Asian Journal of Research in Nephrology Diagnostic Accuracy of Antenatal Ultrasound in Diagnosis of Multicystic Dysplastic Kidneys https://journalajrn.com/index.php/AJRN/article/view/30104 <p><strong>Objective: </strong>To establish the diagnostic accuracy of prenatal detection of unilateral and bilateral MCDK at our tertiary foetal medicine center and identify the association of MCDK with other renal or extra-renal abnormalities.</p> <p><strong>Methods: </strong>This was a retrospective observational study of all the MCDK cases diagnosed either antenatally or postnatally between January 2009 and December 2018 in our tertiary center.</p> <p><strong>Results: </strong>We identified 70 cases that were suspected or diagnosed with MCDK in the 10 year period. 11 cases were suspected to have bilateral disease antenatally opted for termination of pregnancy. However these could not be confirmed as post-mortem data was not available. 2 cases had miscarriages due to associated co-morbidities.</p> <p>Correct antenatal diagnosis was made in 43 cases, 7 cases were false positive as alternative postnatal diagnosis was made and remaining 7 cases were found to have normal scans. Amongst false positive cases hydronephrosis was found in 3, Cortical Cysts in 2 cases and no abnormality in 2 cases postnatally. Associated renal or extra renal abnormalities were found in 13 patients.</p> <p><strong>Conclusions: </strong>The diagnostic accuracy of antenatal ultrasound in our center was 86% with a positive predictive value of 0.8. Associated anomalies were found in 19% of patients. This is comparable to published figures and can be used to guide antenatal counselling accurately.</p> Ahmed Osama Mohamed Sagar Sharma Tommy Mousa Ashok Rajimwale ##submission.copyrightStatement## 2020-09-21 2020-09-21 1 5 Nephroprotective Effect of Khar-E-Khasak Khurd (Tribulus terristris Linn) on Gentamicin-Induced Experimental Nephrotoxicity in Rats https://journalajrn.com/index.php/AJRN/article/view/30105 <p><strong>Background:</strong> Aminoglycoside-Gentamicin is an effective antibiotic against Gram-negative bacterial infections and used in allopathic clinical practice. But its nephrotoxicity limits its frequent clinical use. Unani system of Medicine (USM) has a unique description for tonic (Muqawwiyat) of many vital organs e.g. heart, brain, eye, kidney, and liver. In Unani classics many nephroprotective drugs have been mentioned by the scholars, Khar-e-Khasak Khurd (KKK) is one of them. This study was designed to evaluate the nephroprotective effect of KKK powder on gentamicin-induced nephrotoxicity in rats.</p> <p><strong>Methods:</strong> Albino rats of Wistar strain of either sex were divided into four groups, each having six animals. Nephrotoxicity was induced by giving gentamicin 100-mg/kg b.w/day/subcutaneous in neck region for four days. Gentamicin-administered rats were treated with powder of KKK (840 and 1680 mg/kg/Day) the treatment was started 3 days before the administration of gentamicin while it was continued for 14 days from the day of gentamicin administration.</p> <p><strong>Results:</strong> Administration of gentamicin significantly increased the Blood Urea nitrogen &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(BUN)-155% serum creatinine (SC)-187% and Serum Uric Acid (SUA)-123% levels. The oral administration of KKK (840 mg/kg) inhibited the rise in blood urea (47.09%), serum creatinine (95.93%) and uric acid (51.41%). There were 70.79% inhibition in the rise of BUN, 72.35% &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;inhibition in the rise of serum creatinine and 79.35% inhibition in the rise of uric acid with 1680mg (KKK).</p> <p><strong>Conclusion: </strong>KKK powder has a potential to prevent gentamicin-induced experimental nephrotoxicity in dose dependent manner. The kidney protective effect of KKK powder against gentamicin-induced nephrotoxicity proved the claims of Unani physicians.</p> Farhan Akhtar Misbahuddin Azhar Mohd Aslam Kaleem Javed ##submission.copyrightStatement## 2020-10-10 2020-10-10 6 13 Protective Effect of Aqueous Extract of Moringa oleifera on Nephrotoxicity and Liver Injury Induced by Sodium Chloride in Wistar Albino Rats https://journalajrn.com/index.php/AJRN/article/view/30106 <p>Protective effect of aqueous extract of <em>Moringa oleifera </em>on nephrotoxicity and liver injury induced by sodium chloride in Wistar albino rats was studied. <em>M. oleifera</em> collected from Imo State University School farm was prepared into an extract, and given orally to groups (III, IV and V) of test rats against experimental control rats (group II) that were only induced, alongside with normal control rats (group I) that were neither induced with sodium chloride nor received aqueous extract as treatment. Result of weight changes in rats revealed significant increase (p&lt;0.05) in % weight change of test rats (groups III, IV and V) against the experimental control rats (group II). % weight change in test rats increased insignificantly (p&gt;0.05) when compared to normal control. Urea and creatinine levels significantly reduced (p&lt;0.05) in test rats against experimental control but increased significantly (p&gt;0.05) when compared to those of the normal control. The liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) significantly reduced (p&lt;0.05) when compared to those of experimental control. The ameliorating effect as observed in test rats against the experimental control rats in this study, could be as a result of <em>M.oleifera</em> extract. The extract may have offered a protective effect against the severity of the induced sodium chloride in the test rats. This study has revealed the protective effect of aqueous extract of <em>M.oleifera </em>on nephrotoxicity and liver injury induced by sodium chloride in Wistar albino rats.</p> Nwadike Constance Oly-Alawuba Nkeiruka Dike-Ndudim Joy Nosiri Chidi Ijeoma Ezekwe Ahamefula Akanazu Chidimma ##submission.copyrightStatement## 2020-10-20 2020-10-20 14 21 Assessment of Treatment Adherence and Its Predictors in Maintenance Hemodialysis Patients https://journalajrn.com/index.php/AJRN/article/view/30107 <p><strong>Introduction: </strong>End Stage renal disease (ESRD) is an irreversible progressive condition responsible for high morbidity and mortality. Long term treatment and lifestyle modifications are difficult to adapt which significantly impairs treatment adherence and quality of life.&nbsp;</p> <p><strong>Aim: </strong>To assess the treatment adherence of ESRD patients undergoing maintenance hemodialysis.&nbsp; <strong>Methodology:</strong> A prospective, observational, comparative, multicentre study was done for 10 months. Demographic and clinical parameters were collected from medical records and their treatment adherence was assessed using End-Stage Renal Disease-Adherence Questionnaire (ESRD-AQ). The responses were scored and identified the patients having low adherence.</p> <p><strong>Results:</strong> A total of 121 patients were enrolled in the study with a mean age of 62.14± 11.41 years. Dietary adherence and fluid restriction were observed at 63.33% and 60.33% respectively. Adherence to hemodialysis sessions indicated 97% while towards medication was 67.77%. A significant correlation existed between clinical biomarkers with specific adherence scores which suggest the validity of reported adherence scores. Awareness of patients regarding the diet, fluids, and, medications through patient counselling was found to be very effective in improving the adherence in ESRD populations.&nbsp;</p> <p><strong>Conclusion: </strong>The study concludes that a huge number of hemodialysis patients are non-adherent to the treatment and the pharmacist role is pivotal in improving treatment adherence and patient compliance.</p> Edwin Antony Maria James Anjitha Roy Shaji George ##submission.copyrightStatement## 2020-10-21 2020-10-21 22 29