https://journalajrn.com/index.php/AJRN/issue/feed Asian Journal of Research in Nephrology 2024-06-14T09:46:46+00:00 Asian Journal of Research in Nephrology contact@journalajrn.com Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Nephrology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRN/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Nephrology research’. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> https://journalajrn.com/index.php/AJRN/article/view/71 Hematuria as a Common Symptom of the Nutcracker Syndrome: Two Case Reports and Mini-review 2024-01-19T13:03:42+00:00 Cheikh Sara cheikh.sara.11@gmail.com Kharrat Assia Soldi Chaimaa Elouati Achraf Elkhayat Selma Mtioui Nouafal Zamd Mohamed Ali Medkouri Ghizlaine Benghanem Mohamed <p>Nutcracker syndrome results from compression of the left renal vein (LRV), usually in the range formed by the abdominal aorta and the superior mesenteric artery (SMA), leading to stenosis of the aorto-mesenteric part of the left renal vein and dilation of its distal part.</p> <p>The symptomatology remains dominated by abdominal pain and hematuria. Its diagnosis is essentially based on modern imaging means (computed tomography, ultrasound-Doppler, phlebography) and its treatment is controversial. We report two observations of patients, the first admitted for intermittent macroscopic hematuria and the second for incidentally discovered microscopic hematuria, and whose radiological exploration revealed Nutcracker syndrome.</p> 2024-01-19T00:00:00+00:00 Copyright (c) 2024 Sara et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/72 Recent Trends in Risk Factors Associated with Kidney Diseases 2024-01-23T07:46:48+00:00 Okolonkwo Benjamin Nnamdi benbruceph85@gmail.com Ajibo Doris Nnenna George-Opuda Maureen Ibitroko Nwahiri Jude Donatus <p>The kidneys play a vital role in our overall health and well-being. Their ability to filter waste, reabsorb essential nutrients and maintain a balance of fluids and electrolytes in our body is essential for our health. However, various factors such as age-related changes, exposure to toxins, and lifestyle habits can contribute to a decline in kidney function, leading to potential health issues. Therefore, it is crucial to identify the risk factors that can cause kidney damage and take early interventive measures to slow down the progression of chronic kidney disease. By raising awareness of these risk factors, we can work towards preventing the development of chronic kidney disease and reducing the incidence of end-stage renal disease. It is important to note that several of these risk factors are modifiable, and early diagnosis and treatment of kidney disease can prevent severe complications. Through regular check-ups, identifying these risk factors through panels of tests, and taking a proactive approach towards our health, we can ensure that we maintain healthy kidney function and prevent potential health problems. In conclusion, by taking a constructive approach towards our health and being aware of the risk factors that can cause kidney damage, we can work towards maintaining healthy kidney function and preventing chronic kidney disease. Let us prioritize our health and make changes to our lifestyle habits to reduce the risk of kidney disease and ensure our long-term well-being.</p> 2024-01-23T00:00:00+00:00 Copyright (c) 2024 Okolonkwo et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/75 Corticosteroids and Rashes: A Comprehensive Review 2024-03-18T10:15:46+00:00 Shravan Kumar Dholi D. Ruchitha Reddy ruchithareddy055@gmail.com <p>Corticosteroids are the class of medications that are widely used to treat a variety of inflammatory conditions. However, they can also a number of side effects, including rashes. Corticosteroids induces rashes can range in severity from mild to severe can occur on any part of the body. The mechanism by which corticosteroids cause rashes are not fully understood, but they are thought to involve a combination of factor, including immunosuppressant and skin atrophy. A number of risk factor for developing a corticosteroids induced rash have been identified, including the type and potency of corticosteroids used, the duration of use, and the area of application. The management of corticosteroids induces rashes depends on the type of rash and its severity. Mild cases can often be managed by discontinuing the corticosteroid and using a moisturizer. More severe cases may require treatment with prescription medication, such as topical calcineurin inhibitors or pimecrolimus. The best way to prevent corticosteroids induced rashes is to use corticosteroids as direct by the doctor. This includes using the low potential corticosteroids that is effective for your condition and using the corticosteroids for the shortest period of time necessary.</p> 2024-03-18T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/73 Relation of Immunosuppressive Drugs with BK Virus Infection in Renal Allograft Recipient Cases 2024-01-25T11:36:46+00:00 Md. Mustafizur Rahman mustafizm35@gmail.com Sondipon Malaker Md. Shaheen Reza Amir Mohammad Kaiser Salahuddin Feroz <p><strong>Background: </strong>Human polyoma viruses are the members of the papova virus family. The most known species of this kind are BK-virus (BKV), JC-virus (JCV) and Simian-virus (SV-40). BK (polyma) virus causes allograft dysfunction in renal transplant recipients. The incidence of BK virus infection among renal transplant recipients in Bangladesh is unknown.</p> <p><strong>Objectives: </strong>To find out the frequency of BK virus infection in renal allograft recipients at sixth month after transplantation.</p> <p><strong>Materials and Methods: </strong>This cross-sectional study was carried out in the Department of Nephrology at BSMMU, Dhaka. A total of 29 adult patients who fulfilled the inclusion and exclusion criteria were enrolled from the period of July 2015 to June 2016 by convenient sampling. All relevant information from the renal allograft recipients were collected. Blood and urine of these patients were tested for BK viral DNA by PCR.</p> <p><strong>Results:</strong> The frequency of BK virus infection among the enrolled 29 renal transplanted patients was found to be 20.7%. The mean age of BK virus infected patients was 28.67±11.55 years. Among the 6 patients found infected by BK virus, 5(83.3%) were male. Among the 16 tacrolimus (TAC) treated patients, BK virus was detected in 3(18.7%) patients whereas among the 13 cyclosporin (CIC) treated patients, BK virus was detected in 3(23.1%) patients. 2(33.33%) of the BK virus infected patients developed asymptomatic BK virus infection with impaired graft function.</p> <p><strong>Conclusion: </strong>Our data highlights that BK virus infection is prevalent in our center.</p> 2024-01-25T00:00:00+00:00 Copyright (c) 2024 Rahman et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/74 Hypertension in Renal Transplant Patients: A Prospective Descriptive and Analytical Study 2024-02-24T09:23:38+00:00 Ghattas Mohamed Amine ghattasamine@gmail.com Kharrat Assia Medkouri Ghislaine Naoufal Mtioui Selma Elkhayat Mohamed Ali Zamd Mohamed Benghanem Gharbi <p>The prevalence of hypertension in kidney transplant patients is significant. The physiological circadian evolution of blood pressure (BP) shows a nocturnal decrease of 10 to 20%, called dipping rate. According to this dipping rate, several profiles have been determined, some of which were correlated with the occurrence of cardiovascular events. We set two main objectives for this study: to evaluate the prevalence of hypertension in kidney transplant patients and to determine the dipping rate of hypertensive transplant patients in our series, and its impact on albuminuria. 62 renal transplant patients were included in this study. They underwent 24-hour ambulatory blood pressure measurement (ABPM) with the Suntech AccuWin Pro device in a nephrology department. Arterial hypertension (AH) and dipper status were defined according to the 2018 European Society of Cardiology (ESC) recommendations. A Mann Whitney test assessed the impact of dipper status on albuminuria. The prevalence of hypertension was 52% in a population with a median age of 44 years; 67% of patients had albuminuria &gt;30 mg/24 hours. 3% of hypertensive patients were dippers, 42% of patients were nondippers, and 6% of patients were reverse dippers. A correlation between albuminuria and reverse dipper profile was found with a p = 0.044. In renal transplant recipients, arterial hypertension is a major risk factor of graft loss.&nbsp; Blood pressure control in our population is suboptimal, especially in a population where the impact of nocturnal hypertension on markers of renal damage is well documented.</p> 2024-02-24T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/76 Evaluation of Renal Function and Other Relevant Parameters in Living Kidney Donors after Nephrectomy 2024-04-04T08:37:25+00:00 Rezoyana Nazim dr.esha03@gmail.com Roksana Nazim <p><em><strong>Background: </strong></em><em>Kidney transplantation, especially from a living donor, is a preferred treatment for many with chronic kidney disease (CKD). Unilateral nephrectomy reduces total glomerular filtration rate (GFR), impacting kidney function, arterial hypertension, proteinuria, and other biochemical issues. Evaluation and follow-up of donors are crucial. </em><em>This study aimed to evaluate the renal function and other relevant parameters in living kidney donors after nephrectomy. </em></p> <p><em><strong>Methods:</strong></em><em> This prospective, observational was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2017 to August 2018. A total of 25 adult patients who underwent donor nephrectomy were purposively enrolled as study subjects. Data were analyzed using SPSS version 23.0. </em></p> <p><strong>Results:</strong> Participants' serum creatinine levels significantly (p&lt;0.05) rose at 1-, 3-, 6-, and 12-months post-surgery compared to baseline. Both 24-hour creatinine clearance and eGFR significantly (p&lt;0.05) decreased at 1, 3, 6, and 12 months after surgery. GFR was notably (p&lt;0.05) lower at 6- and 12-months post-surgery. Conversely, 24-hour urinary total protein (UTP) levels significantly (p&lt;0.05) increased at 1, 3, 6, and 12 months after surgery. From baseline to 12 months’ post-donation, serum intact parathyroid hormone and uric acid levels were notably (p&lt;0.05) higher, while hemoglobin, serum calcium, serum phosphorus, and serum albumin levels were significantly (p&lt;0.05) lower. Kidney size showed significant (p&lt;0.05) increases at 1-, 3-, 6-, and 12-months post-surgery.</p> <p><strong>Conclusion:</strong> Living kidney donors may experience a mild decline in glomerular filtration rate (GFR) and biochemical changes following nephrectomy. However, short-term follow-up suggests that outcomes of kidney donation appear safe. Nevertheless, it's crucial to monitor living kidney donors for potential adverse outcomes of donation.</p> 2024-04-04T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/77 Risk of Hypoglycemia during Hemodialysis in Diabetic and Non Diabetic Patients of ESRD: An Observational Study 2024-06-02T08:37:10+00:00 Mohammad Omar Faruque Miah omarmmc80@gmail.com Choman Abdullah Mohana Hasanul Islam Abu Zafor Md. Salahuddin Tasnim Mahmud Tarim Mahmood <p><strong>Background: </strong>Patients with end-stage renal disease (ESRD) regardless of diabetes status are at increased risk of hypoglycemia due to dysregulation of the physiological processes maintaining normal glucose metabolism with a resultant array of adverse clinical outcomes endangering the life of patients.</p> <p><strong>Objective: </strong>The aim of this study is to measure the occurrence of hypoglycemia in patients of ESRD on hemodialysis with or without having diabetes at specified intervals.</p> <p><strong>Methods: </strong>This cross-sectional study will encompass 142 patients with ESRD on dialysis any age group with known ESRD, with or without having diabetes receiving dialysis for &gt;/=3 months. It was be done in dialysis wing, Department of Nephrology of MMCH. The study was occurred from February 2022 to July 2022. Sampling technique was purposive sampling.</p> <p><strong>Result: </strong>Most of the patients (40.8%) were from 46-60 years of age group. In case of gender, male was predominant that was 69.7%. Regarding to diabetes mellitus, majority (80.3%) patients were free from this disease. On the other hand, 62.7% of patients were patient of hypertension. 130 patients had taken dialysis twice per week whereas, only 12 patients had taken dialysis thrice in a week. Most of patients had cardiovascular disease (51.7%) whereas only10.3% patients were affected to diabetic foot. Moreover, most of the patients were found (45.5%) in level 2 hypoglycemia.</p> <p><strong>Conclusion: </strong>Patients were more prone to have level 2 of hyperglycemia in both diabetic and non-diabetic patient. However, the diabetic patient had more chance of co-morbidities along with complications.</p> 2024-06-02T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://journalajrn.com/index.php/AJRN/article/view/78 Association between Vascular Calcification and Residual Renal Function 2024-06-14T09:46:46+00:00 Harunor Rashid Chowdhury harun.nephrology@gmail.com Pradip Kumar Dutta Nurul Huda Rosanna Bintey Kamal Marina Arjumand Mohammad Abdul Kader Tarim Mahmood <p><strong>Introduction:</strong> In chronic kidney disease patients, the leading cause of mortality is cardiovascular disease. In most cases, it is related to vascular calcification. Among multiple risk factors for vascular calcification, decline of residual renal function is an important one. So far, there is scarce information about the influence of residual renal function on vascular calcification in haemodialysis patients.</p> <p><strong>Objective: </strong>To determine the association between vascular calcification and left ventricular hypertrophy in haemodialysis patients with low residual renal function.</p> <p><strong>Methods:</strong> An observational study was performed on 60 chronic kidney disease patients on maintenance haemodialysis with low renal residual function attending in dialysis units of Chittagong Medical College Hospital in Bangladesh during the period from April 2018 to March 2019. Blood samples for biochemical analysis were collected in fasting condition. At the same day, lateral lumbar radiography and M mode echocardiography was done for vascular calcification score and left ventricular hypertrophy respectively.</p> <p><strong>Results:</strong> The prevalence of vascular calcification was present in 88.3% cases in patients with low residual renal function. Patients without vascular calcification had normal left ventricular mass index in 100% cases and those with vascular calcification had increased left ventricular mass index in 75% cases, which was very highly significant. The duration of dialysis, age, gender and smoking were not statistically significant for vascular calcification. There was positive correlation of vascular calcification with fasting blood sugar, C-reactive protein, intact Parathormone, Cholesterol, body mass index, serum calcium, serum phosphate, calcium phosphate product and systolic blood pressure but it was negative for serum albumin, diastolic blood pressure and 24 hours urinary total volume.</p> <p><strong>Conclusion: </strong>Vascular calcification is very common in patients with end stage renal disease on maintenance haemodialysis. Loss of residual renal function is an important risk factor for vascular calcification. Patients with vascular calcification had significantly raised left ventricular mass index.</p> 2024-06-14T00:00:00+00:00 Copyright (c) 2024 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.