https://journalajrn.com/index.php/AJRN/issue/feed Asian Journal of Research in Nephrology 2020-08-07T07:31:55+00:00 Asian Journal of Research in Nephrology contact@journalajrn.com Open Journal Systems <p style="text-align: justify;"><strong>Asian Journal of Research in Nephrology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRN/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Nephrology research’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> https://journalajrn.com/index.php/AJRN/article/view/30099 Nephro and Hepatotoxic Effect of Air-Freshener in Wistar Rats 2020-07-30T10:05:45+00:00 Augustine I. Airaodion augustineairaodion@yahoo.com Oladeji J. Alabi Emmanuel O. Ogbuagu Festus A. Atiba Dolapo S. Olawoyin <p><strong>Aim:</strong> The present study was designed to examine the effect of inhaling ‘sunlight’ air-freshener on renal and hepatic indices of Wistar rats.</p> <p><strong>Methodology:</strong> Thirty Wistar rats were divided into three groups of ten each and kept in different rooms. Rats in group 1 were not exposed to any substance; those in groups 2 and 3 were exposed to sunlight air freshener for 8 hours daily for 28 days by inhalation. After 28 days of exposure, animals in group 3 were allowed to recover for 14 days. Throughout the experiment, all animals were fed <em>ad </em><em>libitum</em> with standard feed and drinking water. At the end of the experiment, rats &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected <em>via</em> cardiac puncture. Hepatic and renal indices were determined using standard &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;methods.</p> <p><strong>Results:</strong> Air-freshener significantly (p&lt;0.05) increased hepatic and renal indices investigated when compared to those in animals in the control group. The effect on hepatic indices was reversed when animals were allowed to recover for 7 days after 28 days exposure. However, the effect on renal indices was sustained after 7 days recovery period.</p> <p><strong>Conclusion:</strong> The results of this study suggest that frequent exposure to air-fresheners poses a dangerous risk to the health of the liver and kidney. This is due to the presence of toxic chemicals such as the volatile organic compounds, which are toxic even at very low concentration, thus proper awareness should be conducted to educate consumers on the risk associated with the frequent use of this product.</p> 2020-07-30T00:00:00+00:00 ##submission.copyrightStatement## https://journalajrn.com/index.php/AJRN/article/view/30100 Effect of Cyperus esculentus L. (Tiger Nut) Milk on Hepatic and Renal Indices of Wistar Rat 2020-08-07T07:31:55+00:00 Augustine Ikhueoya Airaodion Emmanuel Onyebuchi Ogbuagu <p><strong>Background:</strong> Recently, death arising from hepatic and renal related diseases is on the increase; thus, several researches have focused on plant materials with hepato- and nephron-protective potentials.</p> <p><strong>Aim:</strong> This study therefore sought to investigate the effect of tiger nut on hepatic and renal indices of Wistar rats.</p> <p><strong>Materials and Methods:</strong> Twenty-four Wistar rats were divided into four groups of six each. Animals in group A were administered normal saline solution while those in groups B, C and D were administered 1, 2 and 4 mL/kg body weight of undiluted tiger nut&nbsp; milk respectively for twenty-eight days. Administration was done 12 hourly <em>via </em>oral route. At the end of the administration, the rats were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected via cardiac puncture. Hepatic and renal indices were determined using standard methods.</p> <p><strong>Results:</strong> Tiger nut milk was observed to decrease the activities of serum AST, ALT and ALP (hepatic biomarker enzymes). The decrease was only significant (p&lt;0.05) when the activities of AST and ALT of animals treated with 4 mL/kg body weight of tiger nut milk were compared with those in control animals. Similarly, tiger nut milk was observed to decrease the serum concentrations of creatinine and urea. The decrease was only significant (p&lt;0.05) when the concentration of urea of animals treated with 2 and 4 mL/kg body weight of tiger nut milk were respectively compared with those in control animals.</p> <p><strong>Conclusion: </strong>Observations from this study showed that tiger nut has positive effect on hepatic and renal indices; thus possesses hepato- and nephro-protective potentials. Consumption of this plant tuber is recommended for healthy liver and kidneys.</p> 2020-08-07T00:00:00+00:00 ##submission.copyrightStatement##