Nephrotic Syndrome Revealing Secondary Syphilis in a 23-year-old Student in Sub-Saharan Africa and Review of the Literature
Published: 2024-09-19
Page: 90-96
Issue: 2024 - Volume 7 [Issue 1]
Dianda Alassane *
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso and Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.
Sanou Gaoussou
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso.
Bonzi Yérémadé. Juste
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso and Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.
Kadio Sati Ahmed
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso.
Pankolo Macaire
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso and Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.
Kawané Kevin Ulrich
Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso and Department of Nephrology and Hemodialysis, Bogodogo University Hospital, Ouagadougou, Burkina Faso.
Kienou Abdias
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso and Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.
Ouédraogo Gafourou Arsène
Department of Infectious Diseases, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso.
Traoré Abdoul Hassane Sanlé
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso.
Coulibaly Gérard
Department of Nephrology and Hemodialysis, Yalgado Ouédraogo University Hospital, Ouagadougou, Burkina Faso and Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso.
*Author to whom correspondence should be addressed.
Abstract
Glomerulonephritis is one of the renal damages of secondary syphilis.
We report the case of a 23-year-old man, a student with progressive bilateral glaucoma, who consulted nephrology for the oedema to-ascitic syndrome. Clinical and laboratory examination revealed painless generalised edema, syphilitic roseola, nephrotic range proteinuria (10.26 g/24h), severe hypoalbuminemia (16.2 g/l) and hypercholesterolemia. The diagnosis of nephrotic syndrome secondary to syphilis was made and confirmed by positive serology (VDRL and TPHA). After four weeks treatment with anti biotic, significant regression of proteinuria (140mg/24h) and normalization of biological parameters were observed. This case illustrates the importance of early diagnosis and appropriate treatment of nephrotic syndrome secondary to syphilis, enabling rapid and complete recovery.
Keywords: Nephrotic syndrome, secondary syphilis, Subsaharan Africa