Evaluation of Renal Function and Other Relevant Parameters in Living Kidney Donors after Nephrectomy

Rezoyana Nazim *

Department of Nephrology, Evercare Hospital, Dhaka, Bangladesh.

Roksana Nazim

Department of Obstetrics and Gynecology, Labaid Specialized Hospital, Dhaka, Bangladesh.

*Author to whom correspondence should be addressed.


Abstract

Background: Kidney transplantation, especially from a living donor, is a preferred treatment for many with chronic kidney disease (CKD). Unilateral nephrectomy reduces total glomerular filtration rate (GFR), impacting kidney function, arterial hypertension, proteinuria, and other biochemical issues. Evaluation and follow-up of donors are crucial. This study aimed to evaluate the renal function and other relevant parameters in living kidney donors after nephrectomy.

Methods: This prospective, observational was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2017 to August 2018. A total of 25 adult patients who underwent donor nephrectomy were purposively enrolled as study subjects. Data were analyzed using SPSS version 23.0.

Results: Participants' serum creatinine levels significantly (p<0.05) rose at 1-, 3-, 6-, and 12-months post-surgery compared to baseline. Both 24-hour creatinine clearance and eGFR significantly (p<0.05) decreased at 1, 3, 6, and 12 months after surgery. GFR was notably (p<0.05) lower at 6- and 12-months post-surgery. Conversely, 24-hour urinary total protein (UTP) levels significantly (p<0.05) increased at 1, 3, 6, and 12 months after surgery. From baseline to 12 months’ post-donation, serum intact parathyroid hormone and uric acid levels were notably (p<0.05) higher, while hemoglobin, serum calcium, serum phosphorus, and serum albumin levels were significantly (p<0.05) lower. Kidney size showed significant (p<0.05) increases at 1-, 3-, 6-, and 12-months post-surgery.

Conclusion: Living kidney donors may experience a mild decline in glomerular filtration rate (GFR) and biochemical changes following nephrectomy. However, short-term follow-up suggests that outcomes of kidney donation appear safe. Nevertheless, it's crucial to monitor living kidney donors for potential adverse outcomes of donation.

Keywords: Renal function, living kidney donors, nephrectomy, serum creatinine, hemoglobin, serum albumin


How to Cite

Nazim, Rezoyana, and Roksana Nazim. 2024. “Evaluation of Renal Function and Other Relevant Parameters in Living Kidney Donors After Nephrectomy”. Asian Journal of Research in Nephrology 7 (1):49-57. https://journalajrn.com/index.php/AJRN/article/view/76.


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