Ascorbic Acid: A Prophylaxis Drug Therapy for Depression in Female Dam Rats

Main Article Content

Himesh Soni
Richa Swarnkar
Jitender K. Malik

Abstract

Ascorbic acid is extremely concentrated in the brain, being considered as a neuro-modulator. This vitamin possesses antioxidant properties due to its action either as an electron donor or as broad-spectrum radical scavenge. Maternal separation is used in a large number of studies on anti-depression. The present study demonstrates the long-term effect of ascorbic acid (10 mg/kg p.o) on maternal separation (MS) by isolation stress on the emotionality behaviour of female dam rats. The assessment of the 5-HT level in brain was analysed by HPLC, which revealed increased level of 5-HT when compared with control. Locomotor activity and FST showed that there were increased in % swimming & % climbing. Therefore, present finding relevance of ascorbic acid for the treatment of depression and as a co-adjuvant treatment with antidepressants.

Keywords:
Ascorbic acid, MS, FST, serotonin (5-HT).

Article Details

How to Cite
Soni, H., Swarnkar, R., & Malik, J. K. (2020). Ascorbic Acid: A Prophylaxis Drug Therapy for Depression in Female Dam Rats. Asian Journal of Research in Nephrology, 3(1), 9-16. Retrieved from https://journalajrn.com/index.php/AJRN/article/view/30095
Section
Original Research Article

References

Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008; 455:894-902.

Conwell Y, Duberstein PR, Cox C, Herrmann JH, Forbes NT, Caine ED. Relationships of age and axis I diagnoses in victims of completed suicide: A psychological autopsy study. American Journal of Psychiatry. 1996;153:1001-1008.

Kumari P. Overview on: Characteristic of isoflavones & its biological activity International Journal of Biology, Pharmacy and Allied Science. 2017;6(3):447-467.

Jorm AF. History of depression as a risk factor for dementia: An updated review. Australia and New Zealand Journal of Psychiatry. 2001;35:776-781.

Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology Churchill Livingstone. 2007; 6:557.

Murray CJL, Lopez AD. The Global Burden of Disease. Geneva, World Health Organisation; 2001.

Kessler RC. Epidemiology of women and depression. Journal of Affective Disorder. 2003;74(1): 5-13.

Berton O, Nestler EJ. New approaches to antidepressant drug discovery: Beyond monoamines. Nature Reviews Neuro-science. 2006;7:137-51.

Tripathi KD. Essentials of Medical Pharmacology. Jaypee brothers medical publishers (P) Ltd. 2008;16:448.

Basu TK, Dickerson JWT. Vitamins in Human Health and Disease. I ed.UK: Cab International Oxford; 1996.

Brody T. Nutritional Biochemistry Sydney. I ed. london: Academic Press; 1994.

Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999; 69:1086–1107.

Himesh Soni et al. Quantification of ascorbic acid in Salad components. IJCPR. 2011;4(1),43-47.

Himesh Soni et al. Quantification of Ascorbic acid in leaves of Annona squamosa. International Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(3):144-147.

Ricardo W. Binfare, Angelo O. Rosa, Kelly R. Lobato, Adair RS. Santos, Ana Lucia S Rodrigues. Ascorbic acid administration produces an antidepressant-like effect: Evidence for the involvement of monoaminergic neurotransmission. Progress in Neuro Psychopharmacology & Biological Psychiatry. 2009;33:530–540.

Kallen VL, Tulen JH, Utens EM. Association between HPA axis functioning and anxiety in children and adolescents with an anxiety disorder. Depress Anxiety. 2008;25:131-41.

Gerhard Vogel H. Drug discovery and evaluation: Pharmacological assays. Library of Congress Cataloging-in-Publication Data. Springer-Verlag Berlin Heidelberg New York. 2002;(6):561.

Frances Henritte, Danti Sabine, Fermanian Jacques. Effect of Tricyclic antidepressant drugs in the isolation-induced social behaviour deficit test. Progress in Neuro-psychopharmacology and Biology Psychiatry. 1989;13:229-235.

Lee HJ, Kim JW, Yim SV, Kim MJ. Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats. Molecular Phychiatry. 2001;6:725-728.

Luc Zimmer, Latifa Rbah, Fabrice Giacomelli, Didier Le Bars. A Reduced Extracellular Serotonin Level Increases the 5-HT1A PET Ligand 18F MPPF Binding in the Rat Hippocampus. Jounal of Nuclear Medicine. 2003;44:1495–1501.

Pilkington K, Rampes H, Richardson J. Complementary medicine for depression. Expert Rev Neurother. 2006;6:1741-51.

S Jain, Evaluation of Anxiolytic activity of Boerhaavia Diffusa Hydro-Alcoholic extract of leaves in rats African Journal of Pharmacy and Pharmacology. 2011;2(10): 90-92.