Main Article Content
Ascorbic acid is extremely concentrated in the brain, being considered as a neuro-modulator. This vitamin possesses antioxidant properties due to its action either as an electron donor or as broad-spectrum radical scavenge. Maternal separation is used in a large number of studies on anti-depression. The present study demonstrates the long-term effect of ascorbic acid (10 mg/kg p.o) on maternal separation (MS) by isolation stress on the emotionality behaviour of female dam rats. The assessment of the 5-HT level in brain was analysed by HPLC, which revealed increased level of 5-HT when compared with control. Locomotor activity and FST showed that there were increased in % swimming & % climbing. Therefore, present finding relevance of ascorbic acid for the treatment of depression and as a co-adjuvant treatment with antidepressants.
Conwell Y, Duberstein PR, Cox C, Herrmann JH, Forbes NT, Caine ED. Relationships of age and axis I diagnoses in victims of completed suicide: A psychological autopsy study. American Journal of Psychiatry. 1996;153:1001-1008.
Kumari P. Overview on: Characteristic of isoflavones & its biological activity International Journal of Biology, Pharmacy and Allied Science. 2017;6(3):447-467.
Jorm AF. History of depression as a risk factor for dementia: An updated review. Australia and New Zealand Journal of Psychiatry. 2001;35:776-781.
Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology Churchill Livingstone. 2007; 6:557.
Murray CJL, Lopez AD. The Global Burden of Disease. Geneva, World Health Organisation; 2001.
Kessler RC. Epidemiology of women and depression. Journal of Affective Disorder. 2003;74(1): 5-13.
Berton O, Nestler EJ. New approaches to antidepressant drug discovery: Beyond monoamines. Nature Reviews Neuro-science. 2006;7:137-51.
Tripathi KD. Essentials of Medical Pharmacology. Jaypee brothers medical publishers (P) Ltd. 2008;16:448.
Basu TK, Dickerson JWT. Vitamins in Human Health and Disease. I ed.UK: Cab International Oxford; 1996.
Brody T. Nutritional Biochemistry Sydney. I ed. london: Academic Press; 1994.
Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999; 69:1086–1107.
Himesh Soni et al. Quantification of ascorbic acid in Salad components. IJCPR. 2011;4(1),43-47.
Himesh Soni et al. Quantification of Ascorbic acid in leaves of Annona squamosa. International Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(3):144-147.
Ricardo W. Binfare, Angelo O. Rosa, Kelly R. Lobato, Adair RS. Santos, Ana Lucia S Rodrigues. Ascorbic acid administration produces an antidepressant-like effect: Evidence for the involvement of monoaminergic neurotransmission. Progress in Neuro Psychopharmacology & Biological Psychiatry. 2009;33:530–540.
Kallen VL, Tulen JH, Utens EM. Association between HPA axis functioning and anxiety in children and adolescents with an anxiety disorder. Depress Anxiety. 2008;25:131-41.
Gerhard Vogel H. Drug discovery and evaluation: Pharmacological assays. Library of Congress Cataloging-in-Publication Data. Springer-Verlag Berlin Heidelberg New York. 2002;(6):561.
Frances Henritte, Danti Sabine, Fermanian Jacques. Effect of Tricyclic antidepressant drugs in the isolation-induced social behaviour deficit test. Progress in Neuro-psychopharmacology and Biology Psychiatry. 1989;13:229-235.
Lee HJ, Kim JW, Yim SV, Kim MJ. Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats. Molecular Phychiatry. 2001;6:725-728.
Luc Zimmer, Latifa Rbah, Fabrice Giacomelli, Didier Le Bars. A Reduced Extracellular Serotonin Level Increases the 5-HT1A PET Ligand 18F MPPF Binding in the Rat Hippocampus. Jounal of Nuclear Medicine. 2003;44:1495–1501.
Pilkington K, Rampes H, Richardson J. Complementary medicine for depression. Expert Rev Neurother. 2006;6:1741-51.
S Jain, Evaluation of Anxiolytic activity of Boerhaavia Diffusa Hydro-Alcoholic extract of leaves in rats African Journal of Pharmacy and Pharmacology. 2011;2(10): 90-92.